Author

Alex Alderton

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:eQTL / molecular QTL mapping· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Andreas LehaiD· 3 shared Angus I. LamondiD· 3 shared Dalila BensaddekiD· 3 shared Ewan BirneyiD· 3 shared Francesco Paolo CasaleiD· 3 shared Helena KilpineniD· 3 shared Ian StreeteriD· 3 shared Laura ClarkeiD· 3 shared

Activity by Year

2016-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Andreas LehaORCID

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Author profile →

4 papers

Recent·Most cited

Patterns of within-host genetic diversity in SARS-CoV-2

Gerry Tonkin-Hill, Iñigo Martincorena, Roberto Amato, Andrew R J Lawson, Moritz Gerstung, Ian Johnston, David K Jackson, Naomi R Park, Stefanie V Lensing, Michael A Quail, Sónia Gonçalves, Cristina Ariani, Michael Spencer Chapman, William L Hamilton, Luke W Meredith, , Dominic Kwiatkowski

This study analyzes within-host genetic diversity in 1,181 SARS-CoV-2 samples, finding high mutation rates, strand asymmetries, and purifying selection, with implications for transmission chain reconstruction.

eLife · Aug 13, 2021Peer-reviewedGenomics

Population-scale proteome variation in human induced pluripotent stem cells

Bogdan Andrei Mirauta, Daniel D. Seaton, Dalila Bensaddek, Alejandro J. Brenes, Marc Jan Bonder, Helena Kilpinen, Chukwuma A. Agu, Alex Alderton, Petr Danecek, Rachel Denton, Richard Michael Durbin, Daniel J. Gaffney, Ângela Gonçalves, Reena Halai, Sarah Harper, , Philip L. Beales

The paper characterizes proteome variation across 202 human iPSC lines, identifies 700 pQTLs, and links pQTLs to disease-associated GWAS variants.

eLife · Aug 10, 2020Peer-reviewedGenomics

Single-cell RNA-seq of differentiating iPS cells reveals dynamic genetic effects on gene expression

Anna S. E. Cuomo, Daniel D. Seaton, Davis James McCarthy, Iker Martinez, Marc Jan Bonder, José Garcia‐Bernardo, Shradha Amatya, Pedro Madrigal, Abigail Isaacson, Florian Buettner, Andrew J. Knights, Kedar Nath Natarajan, Chukwuma A. Agu, Alex Alderton, Petr Danecek, , Oliver Stegle

The paper uses single-cell RNA-seq of differentiating iPS cells from 125 donors to identify expression quantitative trait loci influencing gene expression during endoderm differentiation.

Nature Communications · Feb 10, 2020Peer-reviewedGenomics

Common genetic variation drives molecular heterogeneity in human iPSCs

Helena Kilpinen, Angela Goncalves, Andreas Leha, Vackar Afzal, Sofie Ashford, Sendu Bala, Dalila Bensaddek, Francesco Paolo Casale, Oliver Culley, Petr Danacek, Adam Faulconbridge, Peter Harrison, Davis McCarthy, Shane A McCarthy, Ruta Meleckyte, , Daniel J Gaffney

This study analyzes 522 human iPSCs to identify genetic sources of phenotypic variation, finding 5-25% of variation in traits like differentiation capacity is due to individual differences.

bioRxiv · May 25, 2016Genomics