Ângela Gonçalves

Non-invasive forecasting of skin cancer evolution through longitudinal hair sampling

This study tracks somatic mutation evolution in hair follicles to forecast early skin cancer development non-invasively.

Cell-of-Origin, not Oncogenic Effect, Determines esmoplastic Immune Exclusion in KRAS-Driven Liver Cancer

This study shows that the cell-of-origin, not oncogenic pathway activation, determines the desmoplastic immune-excluded tumor microenvironment in KRAS-driven liver cancer.

De novo genome assembly of Ansell's mole-rat (Fukomys anselli)

The paper presents a high-quality de novo genome assembly of Ansells mole-rat using long-read, short-read, and Hi-C data, enabling genetic and phylogenetic studies.

The function and decline of the female reproductive tract at single-cell resolution

This study maps the single-cell transcriptional and morphological changes in the mouse female reproductive tract across the estrus cycle, decidualization, and aging, revealing age-related fibrosis and inflammation.

Superovulation and aging perturb oocyte-granulosa cell communication

This study investigates how superovulation and aging affect oocyte-granulosa cell communication in mice, finding that both disrupt similar gene sets and impair oocyte quality.

Signatures Of TSPAN8 Variants Associated With Human Metabolic Regulation And Diseases

The paper identifies TSPAN8 variants associated with metabolomic regulation and metabolic diseases using CNV analysis and functional characterization in human induced pluripotent stem cells.

Population-scale proteome variation in human induced pluripotent stem cells

The paper characterizes proteome variation across 202 human iPSC lines, identifies 700 pQTLs, and links pQTLs to disease-associated GWAS variants.

Single-cell RNA-seq of differentiating iPS cells reveals dynamic genetic effects on gene expression

The paper uses single-cell RNA-seq of differentiating iPS cells from 125 donors to identify expression quantitative trait loci influencing gene expression during endoderm differentiation.

Reconstructing the human first trimester fetal-maternal interface using single cell transcriptomics

The paper profiles single-cell transcriptomes from the human first trimester fetal-maternal interface, revealing cellular composition and interactions critical for placentation.

Molecular and functional variation in iPSC-derived sensory neurons

The paper maps regulatory variants in iPSC-derived sensory neurons, identifying genetic influences on gene expression, chromatin accessibility, and RNA splicing, with overlaps to disease associations.