Identification of a polymorphism in the N gene of SARS-CoV-2 that adversely impacts detection by a widely-used RT-PCR assay
Manu Vanaerschot, Sabrina A Mann, James T. Webber, Jack Kamm, Sidney M. Bell, John Bell, Si Noon Hong, Minh Phuong Nguyen, Lienna Y. Chan, Karan D. Bhatt, Michelle Tan, Angela M. Detweiler, Alex Espinosa, Wesley C. H. Wu, Joshua Batson, , Emily D. Crawford
The paper identifies a SARS-CoV-2 N gene polymorphism that reduces RT-PCR assay sensitivity and emphasizes the need for multi-target testing.
bioRxiv · Aug 25, 2020 · PreprintMolecular Biology