Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors
Fu-Hsuan Ko, Amanda K. Lukens, Mariana Laureano de Souza, Alex Foy, Jason Hsiao, Tolla Ndiaye, John Okombo, Tomas Yeo, Heekuk Park, Anne‐Catrin Uhlemann, Nonlawat Boonyalai, Krittikorn Kümpornsin, Gareth Girling, Charisse Flerida A. Pasaje, Luiz Claudio Godoy, , Elizabeth A. Winzeler
This study identifies divergent resistance mechanisms in Plasmodium HSP90 inhibitors despite shared binding sites, showing that enhanced binding can paradoxically correlate with resistance.
Cell Reports · Jul 1, 2026Peer-reviewedMicrobiology