Author

Amanda K. Lukens

Broad InstituteORCID 0000-0002-9560-7643Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:plant (other)· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Dyann F. WirthiD· 3 shared Elizabeth A. WinzeleriD· 3 shared Sabine OttilieiD· 3 shared David A. FidockiD· 2 shared Matthew AbrahamiD· 2 shared Roy M. WilliamsiD· 2 shared Alex Foy· 1 shared Andrea L. Cheung· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMicrobiology

Dyann F. WirthORCID

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3 papers

Recent·Most cited

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors

Fu-Hsuan Ko, Amanda K. Lukens, Mariana Laureano de Souza, Alex Foy, Jason Hsiao, Tolla Ndiaye, John Okombo, Tomas Yeo, Heekuk Park, Anne‐Catrin Uhlemann, Nonlawat Boonyalai, Krittikorn Kümpornsin, Gareth Girling, Charisse Flerida A. Pasaje, Luiz Claudio Godoy, , Elizabeth A. Winzeler

This study identifies divergent resistance mechanisms in Plasmodium HSP90 inhibitors despite shared binding sites, showing that enhanced binding can paradoxically correlate with resistance.

Cell Reports · Jul 1, 2026Peer-reviewedMicrobiology

Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing

Sabine Ottilie, Madeline R. Luth, Erich Hellemann, Gregory Mark Goldgof, Eddy Vigil, Prianka Kumar, Andrea L. Cheung, Miranda Song, Karla P. Godinez‐Macias, Krypton Carolino, Jennifer H. Yang, Gisel Lopez, Matthew Abraham, Maureen Tarsio, Emmanuelle V. LeBlanc, , Elizabeth A. Winzeler

The paper identifies genetic determinants of chemical resistance in yeast using in vitro evolution and whole genome sequencing, revealing key transcription factors involved in drug resistance.

bioRxiv · Feb 17, 2021 · PreprintGenetics

Mapping The Malaria Parasite Drug-Able Genome Using In Vitro Evolution And Chemogenomics

Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Marı́a G. Gómez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata, Erika L. Flannery, Pamela Magistrado-Coxen, Matthew Abraham, Gregory LaMonte, Roy M. Williams, Virginia Franco, María Linares, Ignacio Arriaga, Selina E. R. Bopp, , Elizabeth A. Winzeler

Whole genome sequencing reveals how Plasmodium falciparum evolves resistance to diverse compounds and identifies new antimalarial drug targets.

bioRxiv · May 22, 2017 · PreprintGenomics