Nonlawat Boonyalai

Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase

The paper identifies potent reaction hijacking inhibitors targeting Plasmodium falciparum asparagine tRNA synthetase, showing high selectivity and resistance refractoriness.

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors

This study identifies divergent resistance mechanisms in Plasmodium HSP90 inhibitors despite shared binding sites, showing that enhanced binding can paradoxically correlate with resistance.

Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials

This paper identifies targets of dual-active antimalarials by evolving resistance to nine compounds and validates them using CRISPR and molecular docking.

Targeting Aurora kinases as essential cell cycle regulators to deliver multi-stage antimalarials against Plasmodium falciparum

The paper identifies PfArk1 as a key target for antimalarial drugs by showing that inhibiting it disrupts parasite mitosis and nuclear division.

The Parasite Intraerythrocytic Cycle and Human Circadian Cycle are Coupled During Malaria Infection

The paper shows that the host circadian cycle and parasite intraerythrocytic cycle are coupled in P. vivax infections, suggesting potential therapeutic targets.

Function and essentiality of Plasmodium falciparum Plasmepsin V

This study functionally inactivates the Plasmodium falciparum plasmepsin V gene using CRISPR-Cas9 and DiCre recombination, showing it is essential for parasite viability in asexual blood stages.