Anne‐Catrin Uhlemann

A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide

This study identifies resistance determinants to antisense antibiotics by analyzing mutations in gram-negative pathogens exposed to CPP-PNA conjugates, revealing adaptation strategies and resistance mechanisms.

Interconnected reservoirs of multidrug-resistant bacteria and plasmids within hospital plumbing infrastructure

The paper characterizes multidrug-resistant bacteria and plasmids in hospital plumbing and finds shared strains between environmental and clinical sources.

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors

This study identifies divergent resistance mechanisms in Plasmodium HSP90 inhibitors despite shared binding sites, showing that enhanced binding can paradoxically correlate with resistance.

Double Mutations in Plasmodium falciparum Kelch13 drive resistance to next-generation artemisinin derivatives in malaria parasites

This study identifies a novel K13 double mutation conferring resistance to ozonide antimalarials in Plasmodium falciparum parasites with existing artemisinin resistance.

A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome

This study develops a machine learning model using oral microbiome data to predict esophageal squamous cell carcinoma, showing good performance across different geographic regions.

Comparative metagenomics using pan-metagenomics graphs

This paper introduces copangraph, a framework for comparative metagenomic analysis using sequence graphs, showing improved accuracy and computational efficiency in capturing genomic variation across microbial communities.

A novel post-translational modification of fimbriae drives pathogenicity in Klebsiella pneumoniae

This study identifies CrrAB as a regulatory system in ST258 Klebsiella pneumoniae that enhances virulence and antibiotic resistance through post-translational modification of fimbriae.

Identification of Sample Processing Errors in Microbiome Studies Using Host Genetic Profiles

The paper identifies sample processing errors in microbiome studies using host genetic profiles from metagenomic sequencing and experimental metadata.

Processing-bias correction with DEBIAS-M improves cross-study generalization of microbiome-based prediction models

DEBIAS-M corrects processing bias in microbiome data, improving cross-study generalization of prediction models by learning interpretable bias-correction factors.

Early prediction of preeclampsia using the first trimester vaginal microbiome

This study predicts preeclampsia using first trimester vaginal microbiome data with machine learning, achieving an auROC of 0.78 in the training set and 0.80 in an independent cohort.

Plasmodium falciparum quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1

This study identifies DMT1 and a chromosome 12 locus, including FtsH1, as novel contributors to Plasmodium falciparum resistance to quinine, alongside the known pfcrt gene.

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

The paper identifies genetic determinants of multidrug resistance in Plasmodium falciparum and their impact on parasite fitness and drug susceptibility.