Genetic Background and Sex Modulate Androgen Responses in Human Brain Microphysiological System
Maren Schenke, Jason Laird, Alex Rittenhouse, Viktoriya Kucheryavenko, Winfried Neuhaus, Ou Chen, Sarven Sabunciyan, Alexandra Maertens, Lena Smirnova
This study shows that androgen responses in human brain organoids vary by genetic background and sex, affecting transcription, cell populations, and DNA methylation.
bioRxiv · Dec 8, 2025 · PreprintNeuroscience