Lena Smirnova

This study uses a 3D finite element model to simulate necrosis in neural organoids and evaluates culture methods to reduce necrosis.

This study evaluates cryopreservation protocols for brain organoids, finding that week 2 cryopreservation yields better functional outcomes than week 6, with 3dGRO showing the best overall performance.

The paper demonstrates neuromodulation in neural organoids using 3D shell MEAs, showing increased neuron firing rates with specific stimulation ranges.

This study shows that androgen responses in human brain organoids vary by genetic background and sex, affecting transcription, cell populations, and DNA methylation.

This study shows that structured firing sequences emerge in human and murine brain organoids and neonatal brain slices, suggesting innate rather than experience-dependent neural coding.

This study demonstrates that human neural organoids exhibit features of learning and memory by showing synaptic plasticity, criticality, and receptor expression.

This paper adapts CEBRA to generate low-dimensional embeddings of neural organoid electrophysiology data for analyzing activity changes and clustering bursting phenomena.

This study develops a glia-enriched 3D brain model from human iPSCs that mimics MS-related neurodegenerative phenotypes and intercellular communication.