Author

Jason Laird

Johns Hopkins UniversityORCID 0009-0000-5994-2236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lena SmirnovaiD· 2 shared Maren SchenkeiD· 2 shared Alex Rittenhouse· 1 shared Alexandra MaertensiD· 1 shared Alon LoeffleriD· 1 shared Amitav Mitra· 1 shared Brett J. KaganiD· 1 shared Dowlette‐Mary Alam El DiniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersNeuroscience

Lena SmirnovaORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJul 17, 2026

Perinatal exposure to individual and a metal mixture induces persistent and sex-specific alterations to the cardiac transcriptome of offspring

Morgan Steiner, Jason Laird, Sylvia S. Sanchez…·Mark Jeffrey Kohr

This study shows perinatal exposure to heavy metals and their mixtures alters cardiac gene expression, cellular composition, and immune signaling in a sex-specific manner in mice.

DOI 10.64898/2026.07.11.737950

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 8, 2025

Genetic Background and Sex Modulate Androgen Responses in Human Brain Microphysiological System

Maren Schenke, Jason Laird, Alex Rittenhouse…·Lena Smirnova

This study shows that androgen responses in human brain organoids vary by genetic background and sex, affecting transcription, cell populations, and DNA methylation.

DOI 10.64898/2025.12.03.692130

humanbulk RNA-seq

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NeuroscienceCommunications BiologyPeer-reviewedAug 16, 2025

Human Neural Organoid Microphysiological Systems Show the Building Blocks Necessary for Basic Learning and Memory

Dowlette‐Mary Alam El Din, Leah S. Mönkemöller, Alon Loeffler…·Lena Smirnova

This study demonstrates that human neural organoids exhibit features of learning and memory by showing synaptic plasticity, criticality, and receptor expression.

28 citationstop 1%

humanscRNA-seq

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