Author

Ou Chen

Johns Hopkins UniversityORCID 0000-0003-2001-3565Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Sarven SabunciyaniD· 2 shared Alex Rittenhouse· 1 shared Alexandra MaertensiD· 1 shared Giulia Irene Maria PasquesiiD· 1 shared Jason LairdiD· 1 shared Lena SmirnovaiD· 1 shared Liliana FloreaiD· 1 shared Maren SchenkeiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Sarven SabunciyanORCID

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2 papers

Recent·Most cited

Genetic Background and Sex Modulate Androgen Responses in Human Brain Microphysiological System

Maren Schenke, Jason Laird, Alex Rittenhouse, Viktoriya Kucheryavenko, Winfried Neuhaus, Ou Chen, Sarven Sabunciyan, Alexandra Maertens, Lena Smirnova

This study shows that androgen responses in human brain organoids vary by genetic background and sex, affecting transcription, cell populations, and DNA methylation.

bioRxiv · Dec 8, 2025 · PreprintNeuroscience

Predicting Alu exonization in the human genome with a deep learning model

Zitong He, Ou Chen, Noelani Phillips, Giulia Irene Maria Pasquesi, Sarven Sabunciyan, Liliana Florea

The paper develops a deep learning model, eXAlu, to predict Alu exonization events in the human genome and estimates their prevalence to be 55-110K, significantly higher than in GENCODE.

bioRxiv · Jan 3, 2024 · PreprintBioinformatics