Sarven Sabunciyan

Genetic Background and Sex Modulate Androgen Responses in Human Brain Microphysiological System

This study shows that androgen responses in human brain organoids vary by genetic background and sex, affecting transcription, cell populations, and DNA methylation.

Predicting Alu exonization in the human genome with a deep learning model

The paper develops a deep learning model, eXAlu, to predict Alu exonization events in the human genome and estimates their prevalence to be 55-110K, significantly higher than in GENCODE.

Comprehensive and scalable quantification of splicing differences with MntJULiP

The paper introduces MntJULiP, a method for accurate quantification of splicing differences, revealing tissue differentiation splicing constituents using hundreds of GTEx samples.

Differential Expression of NPAS4 in the Dorsolateral Prefrontal Cortex Following Acute Opioid Intoxication

The paper compares gene expression in the prefrontal cortex between individuals who died from acute opioid intoxication and controls, finding NPAS4 is downregulated and associated with opioid use.

Epigenome-wide study of brain DNA methylation among opioid users and controls

This study examines DNA methylation in brain tissue from opioid users and controls, finding a significant association between opioid use and phenotypic age but no genome-wide significant CpG sites.

CLASS: Accurate and Efficient Splice Variant Annotation from RNA-seq Reads

CLASS is a tool for accurate splice variant annotation from RNA-seq reads, outperforming existing methods in accuracy and detection of splicing events.