Polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome cellular models
Andres Sola, Alex Sandberg, Caitlin Pham, Alexandra Revier, Mia Hebinck, Alexandra L. Penney, Pablo A. Caviedes, Sunil Kumar, Ann‐Charlotte Granholm, Daniel A. Linseman, Daniel Paredes
This study investigates polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome models, finding that DFMO reduces Aβ42 aggregation and AD-related protein levels in DS fibroblasts.
bioRxiv · Jan 31, 2025 · PreprintBiochemistry