Daniel A. Linseman

This study shows that RNA G-quadruplexes influence TDP43 condensation and toxicity in different cell types, suggesting targeting these structures could be a new approach for treating protein misfolding diseases.

This study investigates polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome models, finding that DFMO reduces Aβ42 aggregation and AD-related protein levels in DS fibroblasts.