This study finds increased RNA G-quadruplex accumulation in aging and Alzheimer's disease hippocampus, linking it to tau aggregation and APOE genotype.

eLife · Feb 24, 2025Peer-reviewedNeuroscience

Polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome cellular models

Andres Sola, Alex Sandberg, Caitlin Pham, Alexandra Revier, Mia Hebinck, Alexandra L. Penney, Pablo A. Caviedes, Sunil Kumar, Ann‐Charlotte Granholm, Daniel A. Linseman, Daniel Paredes

This study investigates polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome models, finding that DFMO reduces Aβ42 aggregation and AD-related protein levels in DS fibroblasts.

bioRxiv · Jan 31, 2025 · PreprintBiochemistry

Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease

Hazal Haytural, Tomás Jordá-Siquier, Bengt G. Winblad, Christophe Mulle, Lars O. Tjernberg, Ann‐Charlotte Granholm, Susanne Frykman, Gaël Barthet

This study identifies reduced presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease, suggesting presynaptic failure in this region.

Brain Communications · Apr 1, 2021Peer-reviewedNeuroscience