Author

Alex Wirganowicz

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Andres E. Gabagat· 1 shared Bálint CsörgőiD· 1 shared Eugene V. KooniniD· 1 shared Joseph Bondy‐DenomyiD· 1 shared Kira S. MakarovaiD· 1 shared Peter WeigeleiD· 1 shared Timothy A. KleiniD· 1 shared Wearn‐Xin YeeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperMicrobiology

Andres E. Gabagat

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1 paper

Recent·Most cited

END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes

Wearn‐Xin Yee, Yan‐Jiun Lee, Timothy A. Klein, Alex Wirganowicz, Andres E. Gabagat, Bálint Csörgő, Kira S. Makarova, Eugene V. Koonin, Peter Weigele, Joseph Bondy‐Denomy

The paper identifies ENDPaCF1, a novel defense system in Pseudomonas aeruginosa, which targets hypermodified phage DNA through an endonuclease domain fused to an inactive Endonuclease III, revealing its role in antiphage immunity.

bioRxiv · Mar 31, 2025 · PreprintMicrobiology