Author

Timothy A. Klein

University of California, San FranciscoORCID 0000-0001-9167-5975Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Joseph Bondy‐DenomyiD· 2 shared Alex Wirganowicz· 1 shared Andres E. Gabagat· 1 shared Bálint CsörgőiD· 1 shared Claire KokontisiD· 1 shared Eugene V. KooniniD· 1 shared Kira S. MakarovaiD· 1 shared Peter WeigeleiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Joseph Bondy‐DenomyORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 31, 2025

END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes

Wearn‐Xin Yee, Yan‐Jiun Lee, Timothy A. Klein…·Joseph Bondy‐Denomy

The paper identifies ENDPaCF1, a novel defense system in Pseudomonas aeruginosa, which targets hypermodified phage DNA through an endonuclease domain fused to an inactive Endonuclease III, revealing its role in antiphage immunity.

4 citations

bacteria (other)proteomics

𝕏 PostBluesky

MicrobiologyNaturePeer-reviewedFeb 5, 2025

Conserved jumbo phage factors required for protein import into a phage nucleus

Claire Kokontis, Timothy A. Klein, Sukrit Silas, Joseph Bondy‐Denomy

The paper identifies conserved phage factors required for protein import into a phage nucleus and characterizes their interactions and roles in selectivity.

21 citationstop 3%

experimental assay

𝕏 PostBluesky