Wearn‐Xin Yee

This study identifies a tripartite mechanism involving Imp7 and Imp1 that licenses RNA polymerase import into the phage nucleus, showing that nuclear compartment assembly precedes transcriptional and replicative programs.

This study develops a phage transposon sequencing (TnSeq) platform to identify essential genes in bacteriophages, finding ~110 fitness-conferring genes in a jumbo phage model.

The paper identifies surface receptor masking and internal defenses as barriers to phage therapy in Pseudomonas aeruginosa clinical isolates and presents strategies to overcome these barriers through phage engineering.

The paper shows phase-variable restriction modification systems in Neisseria gonorrhoeae limit plasmid transmission, affecting antimicrobial resistance spread.

The paper identifies ENDPaCF1, a novel defense system in Pseudomonas aeruginosa, which targets hypermodified phage DNA through an endonuclease domain fused to an inactive Endonuclease III, revealing its role in antiphage immunity.