Integrative Multiomic Analysis Reveals How Non-Viral Delivery System Selection Shapes CRISPR Gene Editing Outcomes in Stem Cells.
Joshua P. Graham, Alexander Arteaga, Abolfazl Salehi Moghaddam, Kara L. Spiller, Daniel J. Laverty, Tomas Gonzalez‐Fernandez
This study compares non-viral CRISPR delivery methods in stem cells, finding that lipid-based delivery offers high efficiency but risks genomic instability, while CPPs reduce side effects at lower efficiency.
bioRxiv · May 30, 2026 · PreprintBioengineering