Boxun Li

Interrogation of noncoding schizophrenia risk variants using CRISPR-based functional genomics

The paper uses CRISPR-based functional genomics to identify noncoding regulatory elements and variants affecting schizophrenia-associated gene expression.

PEPR-GNN: Perturbation-Enhancer-Promoter-RNA Graph Neural Networks for Multiome Perturb-Seq modeling of regulomes

The paper introduces PEPR-GNN, a graph neural network framework to model regulome responses during genetic perturbations using Multiome Perturb-Seq data.

Reprogramming of neuronal genome function and phenotype by astrocytes

This paper shows that astrocytes reprogram neuronal gene expression and chromatin accessibility, affecting thousands of genes and regulatory elements, including those linked to schizophrenia and Alzheimer's disease.

Enhancer-driven regulatory network of forebrain human development provides insights into autism

The paper constructs an enhancer-driven gene regulatory network from human forebrain organoids with ASD and neurotypical controls, identifying key regulators of excitatory neuron specification in macrocephalic ASD.

Rational reprogramming of cellular states by combinatorial perturbation

The paper develops Reprogram-Seq to screen TF cocktails for reprogramming cell states, identifying a 3-TF combination that reprograms MEFs to epicardial-like cells.