Author

Ruhi Rai

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alejandro BarreraiD· 3 shared Charles A. GersbachiD· 3 shared Gregory E. CrawfordiD· 3 shared Michael I LoveiD· 3 shared Patrick F. SullivaniD· 3 shared Alexias SafiiD· 2 shared Andrew S. AlleniD· 2 shared Boxun LiiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Alejandro BarreraORCID

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3 papers

Recent·Most cited

Interrogation of noncoding schizophrenia risk variants using CRISPR-based functional genomics

Marisa C. Hamilton, Julia W. Riley, Alexander C. Nelson, Boxun Li, Sophie F. Dornbaum, Alexias Safi, Xiekui Cui, Ian Richard Jones, Aaron A Coley, Kevin T. Hagy, Ruhi Rai, Alejandro Barrera, Andrew S. Allen, Yin Shen, Richard I. Sherwood, , Gregory E. Crawford

The paper uses CRISPR-based functional genomics to identify noncoding regulatory elements and variants affecting schizophrenia-associated gene expression.

bioRxiv · Sep 17, 2026 · PreprintGenomics

Reprogramming of neuronal genome function and phenotype by astrocytes

Boxun Li, Kevin T. Hagy, Alexias Safi, M Beer, Alejandro Barrera, Sara Geraghty, Ruhi Rai, Alyssa N. Pederson, Samuel J. Reisman, Michael I Love, Patrick F. Sullivan, Çağla Eroğlu, Gregory E. Crawford, Charles A. Gersbach

This paper shows that astrocytes reprogram neuronal gene expression and chromatin accessibility, affecting thousands of genes and regulatory elements, including those linked to schizophrenia and Alzheimer's disease.

bioRxiv · Mar 7, 2026 · PreprintGenomics

Functional Annotation of the Major Histocompatibility Complex Locus

Lexi R. Bounds, Alejandro Barrera, Maria A. ter Weele, Siyan Liu, Euphy Y. Wu, Shengyu Li, Revathy Venukuttan, Ruhi Rai, W. Mu, Nahid Iglesias, Paola Giusti‐Rodríguez, Timothy E. Reddy, Yun Li, Raluca Gordân, Andrew S. Allen, , Charles A. Gersbach

This study identifies hundreds of new cis-regulatory element-gene connections in the MHC locus using CRISPR screens and single-cell transcriptomics, revealing cell type-specific regulatory mechanisms.

bioRxiv · Feb 3, 2026 · PreprintGenomics