ROS Impair Mitophagy via PARylation of PINK1
Liangliang Gao, Heling Wang, Xuxu Zhuang, Dade Rong, Xiang-Zheng Gao, Liming Xie, Zhuo Wang, Mingzhu Tang, Yuehua Chen, Yichi Zhang, Alexander D. Carlsson, Liming Wang, Guang Xiu Lu, Jiahong Lu, Evandro Fei Fang, Han‐Ming Shen
This study shows that ROS inhibit mitophagy by activating PARP1, which PARylates PINK1 and impairs its function.
bioRxiv · Jun 19, 2026 · PreprintCell Biology