Evandro Fei Fang

This study shows that ROS inhibit mitophagy by activating PARP1, which PARylates PINK1 and impairs its function.

This study shows that ATG-18 overexpression extends C. elegans lifespan and improves stress resilience through the HLH-30 transcription factor, while also revealing a temporal-specific effect on heat stress survival.

The paper shows NAD+ and EVA1-C regulate alternative splicing in tauopathies, affecting protein interactions and disease progression, suggesting therapeutic potential for AD.

The paper confirms that Bnip3 expression correlates with reelin levels in entorhinal cortex layer II neurons, indicating higher metabolic demand near the rhinal fissure.

This study shows that Urolithin A improves cognitive function and restores mitophagy and lysosomal functions in Alzheimer's disease mouse models.

This study uses iPSC-derived cortical organoids to model Alpers' disease and shows that nicotinamide riboside improves mitochondrial defects and neuronal loss.