Integrating multiplexing into confineable gene drives effectively overrides resistance in Anopheles stephensi
Mireia Larrosa‐Godall, Lewis Shackleford, Matthew P. Edgington, Philip T. Leftwich, James C. Y. Luk, Joshua Southworth, Stewart Rosell, Jake Creasey, Jack Aked, Katherine Nevard, Alexander Dodds, Morgan Mckee, Eunice O. Adedeji, Estela González, Joshua X. D. Ang, , Luke Alphey
The paper assesses two multiplexing strategies for CRISPR/Cas9-based gene drives in Anopheles stephensi to overcome target site resistance.
bioRxiv · Aug 15, 2025 · PreprintGenetics