The paper investigates fitness differences between knock-in and knock-out cd mutants in Anopheles stephensi, finding that knock-in mutants have reduced survival and midgut dysfunction, while knock-outs do not.

bioRxiv · Jul 9, 2026 · PreprintGenetics

Integrating multiplexing into confineable gene drives effectively overrides resistance in Anopheles stephensi

Mireia Larrosa‐Godall, Lewis Shackleford, Matthew P. Edgington, Philip T. Leftwich, James C. Y. Luk, Joshua Southworth, Stewart Rosell, Jake Creasey, Jack Aked, Katherine Nevard, Alexander Dodds, Morgan Mckee, Eunice O. Adedeji, Estela González, Joshua X. D. Ang, , Luke Alphey

The paper assesses two multiplexing strategies for CRISPR/Cas9-based gene drives in Anopheles stephensi to overcome target site resistance.

bioRxiv · Aug 15, 2025 · PreprintGenetics

Detection of West Nile Virus via Retrospective Mosquito Arbovirus Surveillance in the United Kingdom

Robert C. Bruce, Anthony J. Abbott, Ben P. Jones, Bathsheba L. Gardner, Estela González, Andra‐Maria Ionescu, Madhujot Jagdev, Ava Jenkins, Mariana Santos, Katharina Seilern‐Macpherson, Hugh J. Hanmer, Robert A. Robinson, Alexander G. C. Vaux, Nicholas Johnson, Andrew A. Cunningham, , Arran J. Folly

The paper reports the detection of West Nile virus RNA in mosquito pools from the UK, indicating a historic presence of the virus in the region.

Eurosurveillance · Jul 17, 2025Peer-reviewedMolecular Biology

A CRISPR endonuclease gene drive reveals two distinct mechanisms of inheritance bias

Sebald A. N. Verkuijl, Estela González, Ming Li, Joshua X. D. Ang, Nikolay P. Kandul, Michelle A. E. Anderson, Omar S. Akbari, Michael B. Bonsall, Luke Alphey

This study investigates inheritance bias mechanisms in a CRISPR gene drive in Aedes aegypti, finding two distinct mechanisms: homing in double heterozygous males and meiotic drive.

Nature Communications · Nov 21, 2022Peer-reviewedGenetics