Impaired Chylomicron Secretion Results in Reduced Body Fat and Increased Intestinal Fatty Acid Oxidation by Activation of Autophagy
Khaga Raj Neupane, Alexander Karakashian, Maura Mobilia, Olivia Hage, Patrick Tso, Min Liu, Laurent Vergnes, Karen Reue, Scott M. Gordon
This study shows that DENND5B is critical for dietary triglyceride absorption and that its deletion reduces body fat and increases intestinal fatty acid oxidation via autophagy in both sexes.
bioRxiv · Nov 19, 2025 · PreprintPhysiology