Karen Reue

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more

The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.

Sex-Specific Regulation of Endothelial-to-Mesenchymal Transition (EndMT) During Atherosclerosis

The paper examines sex-specific regulation of EndMT in atherosclerosis using bulk RNA-seq and single-cell transcriptomics, identifying key regulators and stage-dependent differences.

Impaired Chylomicron Secretion Results in Reduced Body Fat and Increased Intestinal Fatty Acid Oxidation by Activation of Autophagy

This study shows that DENND5B is critical for dietary triglyceride absorption and that its deletion reduces body fat and increases intestinal fatty acid oxidation via autophagy in both sexes.

A genome-wide ATLAS of liver chromatin architecture reveals that sex dictates diet-induced nucleosome dynamics

The paper maps liver chromatin architecture using ATAC-seq and shows sex is the main factor driving diet-induced nucleosome dynamics in mice.

Feeding Neurons Integrate Metabolic and Reproductive States in Mice

This study identifies TNSST neurons in mice that modulate feeding behavior based on metabolic and reproductive states, with effects dependent on body mass and estrogen levels.

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

The paper identifies UFMylation as a negative regulator of skeletal muscle function through proteome-wide systems genetics in mice and validates it in a disease model.

Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas

This study shows CNTF treatment in degenerating mouse retinas enhances glycolysis and anabolism, improving neuronal viability through metabolic changes.

Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

The paper investigates the relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in gene regulation in liver and adipose tissues using the FCG mouse model.

Hair regeneration by small molecules that activate autophagy

The paper identifies small molecules that activate autophagy to stimulate hair regeneration in various conditions.