Scott M. Gordon

Preserved CETP Activity and Early Serum Amyloid A are Associated with Improved Outcomes in Sepsis-Associated ARDS

This study identifies CETP activity and early SAA levels as prognostic biomarkers in sepsis-associated ARDS, showing they predict improved survival and reduced disease severity.

Identification of scavenger receptor BI as a scavenger of free heme that is essential for protection against hemolysis

This study identifies scavenger receptor BI as a critical heme scavenger that protects against hemolysis, showing its therapeutic potential in hemolytic disorders.

Postoperative Stress Accelerates Atherosclerosis through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

This study shows that postoperative stress impairs reverse cholesterol transport and accelerates atherosclerosis through inflammatory remodeling of HDL and foam cell apoptosis.

Impaired Chylomicron Secretion Results in Reduced Body Fat and Increased Intestinal Fatty Acid Oxidation by Activation of Autophagy

This study shows that DENND5B is critical for dietary triglyceride absorption and that its deletion reduces body fat and increases intestinal fatty acid oxidation via autophagy in both sexes.

ABCG5 ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high cholesterol diet

This study shows that G5G8-independent mechanisms cannot compensate for G5G8 deficiency in mice fed a high cholesterol diet, leading to sterol accumulation in the liver and plasma.

Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice

This study shows that reducing CPT1a in the liver lowers apoB-containing lipoproteins and cholesterol in mice, with increased clearance of these lipoproteins linked to enhanced PPAR signaling.

APOE4 alters the lipid droplet proteome and modulates droplet dynamics

This study shows that APOE4 increases lipid droplet accumulation and alters their composition in microglia, resembling a pro-inflammatory state, and overlaps with AD-associated proteomes.