Aging and injury drive neuronal senescence in the dorsal root ganglia
Lauren J. Donovan, Chelsie L. Brewer, Sabrina F. Bond, Alexander M Laslavic, Aleishai Pena Lopez, Laura Colman, Claire E. Jordan, Linus Hansen, Oscar Christian Gonzalez, Akshay Pujari, Luı́s de Lecea, Marco Quarta, Julie A. Kauer, Vivianne L. Tawfik
This study identifies neuronal senescence in dorsal root ganglia of aged and injured mice, showing it contributes to sensory dysfunction and is reversible with senolytic treatment.
Nature Neuroscience · May 1, 2025Peer-reviewedNeuroscience