Vivianne L. Tawfik

Library docking for Cannabinoid-2 Receptor ligands

This study uses library docking to identify subtype-selective CB2 receptor ligands, finding improved hit rates and affinities with larger libraries and structure-based optimization.

Linking Pain and Delirium via Microglial Activation: A Mouse Study Using BSEEG, Behavioral Assays, Immunohistochemistry, and RNA Sequencing

This study links neuropathic pain and delirium via microglial activation in mice using combined behavioral, electrophysiological, and transcriptomic analyses.

Psilocybin has no immediate or persistent analgesic effect in acute and chronic mouse pain models

This study shows psilocybin does not have analgesic effects in acute or chronic mouse pain models across various pain types and doses.

Aging and injury drive neuronal senescence in the dorsal root ganglia

This study identifies neuronal senescence in dorsal root ganglia of aged and injured mice, showing it contributes to sensory dysfunction and is reversible with senolytic treatment.

Ethological profiling of pain and analgesia in a mouse model of complex regional pain syndrome.

This study identifies a unique ethological signature of pain in a mouse model of CRPS and evaluates the effects of dexmedetomidine on pain behaviors.

Newly repopulated spinal cord microglia exhibit a unique transcriptome and correlate with pain resolution

The paper shows that newly repopulated spinal cord microglia have a unique transcriptome linked to pain resolution in a tibial fracture model.

Schwann cells promote sensory neuron excitability during development

This study shows Schwann cells promote sensory neuron excitability during development by secreting prostaglandin E2, which is essential for normal sodium channel expression and action potential firing.

Exercise and angiotensin receptor blockade enhance recovery after orthopaedic trauma in mice by decreasing pain and improving muscle regeneration

This study shows that delayed exercise and losartan treatment improve recovery after orthopaedic trauma in mice by reducing pain and muscle fibrosis.