Author

Alexander Sorensen

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:non-human primate· 1 Organism:rat· 1

Frequent Co-Authors

Jonathan D. CooperiD· 2 shared Patricia DicksoniD· 2 shared Steven Q. LeiD· 2 shared Balraj DorayiD· 1 shared Bethann N. ValentineiD· 1 shared Carole A. Vogler· 1 shared Elizabeth M. SnellaiD· 1 shared Feng WangiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Jonathan D. CooperORCID

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2 papers

Recent·Most cited

Reduced heparan sulfate levels in cerebrospinal fluid reflect brain neuron correction in Sanfilippo B mice

Steven Q. Le, Alexander Sorensen, Soila Sukupolvi, Gianna Jewhurst, Grant L. Austin, Balraj Doray, Jonathan D. Cooper, Patricia Dickson

The paper shows that reducing heparan sulfate in cerebrospinal fluid reflects brain neuron correction in Sanfilippo B mice through targeted enzyme delivery.

Journal of Clinical Investigation · Aug 28, 2025Peer-reviewedBiochemistry

Recombinant NAGLU-IGF2 prevents physical and neurological disease and improves survival in Sanfilippo B syndrome

Steven Q. Le, Shih‐hsin Kan, Marie S. Roberts, Joshua T. Dearborn, Feng Wang, Shan Li, Elizabeth M. Snella, Jackie K. Jens, Bethann N. Valentine, Hemanth R. Nelvagal, Alexander Sorensen, Keerthana Chintalapati, Kevin K. Ohlemiller, Carole A. Vogler, Jonathan D. Cooper, , Patricia Dickson

This study shows that rhNAGLU-IGF2 treatment improves disease markers, behavior, and survival in Sanfilippo B mice and dogs.

bioRxiv · Aug 6, 2021 · PreprintNeuroscience