Balraj Doray

This study identifies TMEM251 as a two-transmembrane protein that stabilizes GNPT, prevents its mislocalization, and ensures M6P pathway fidelity through interactions with GOLPH3 and retromer complexes.

The paper identifies an unconventional HxD motif in coronaviruses that functions as a coatomer-binding signal, revealing alternative pathways for viral morphogenesis.

The paper shows that reducing heparan sulfate in cerebrospinal fluid reflects brain neuron correction in Sanfilippo B mice through targeted enzyme delivery.

This study investigates the role of GABAergic interneurons in seizure progression and mortality in CLN2 disease mice, finding that interneuron dysfunction contributes to epileptic seizures and death.

This study uses genome-engineered cells with IDS mutations to identify subtle lysosomal and membrane phenotypes that correlate with genetic variants in the IDS gene, improving the assessment of variant pathogenicity.