Hemanth R. Nelvagal

This paper introduces a non-invasive imaging framework combining qMRI and SRT to infer molecular features in neurodegeneration.

This study investigates the role of GABAergic interneurons in seizure progression and mortality in CLN2 disease mice, finding that interneuron dysfunction contributes to epileptic seizures and death.

This study compares molecular and cellular signatures of Parkinson's disease and Parkinson's disease with dementia using single-nuclear transcriptomics, finding distinct gene expression patterns and biological pathways.

This paper shows gene therapy prevents bowel motility issues and enteric neuron loss in mouse models of lysosomal storage diseases.

This study examines the effects of chronic CBD in a mouse model of neuroinflammation, neurodegeneration, and seizures, finding reduced astrocytosis and microgliosis but no impact on seizures or neuron survival.

This study identifies novel disease phenotypes in Cln2R207X mice, including cortical interneuron loss and seizure generation, providing insights into CLN2 disease pathogenesis.

This study shows that rhNAGLU-IGF2 treatment improves disease markers, behavior, and survival in Sanfilippo B mice and dogs.