Aberrant FICD-mediated AMPylation drives α-Synuclein pathology and overall protein dyshomeostasis in dopaminergic neurons in Parkinson's disease
Aron Koller, Laura Hoffmann, Alexandra Bluhm, Alina Schweigert, Yanni Schneider, Marie Andert, Tobias Becker, Friederike Zunke, Thomas G. Beach, Geidy E. Serrano, Steffen Roßner, Jürgen Winkler, Pavel Kielkowski, Wei Xiang
This study shows that FICD-mediated AMPylation contributes to Parkinson's disease by promoting α-synuclein aggregation and protein dyshomeostasis in dopaminergic neurons.
bioRxiv · Apr 1, 2026 · PreprintNeuroscience