Jürgen Winkler

The paper compares fixation and cryopreservation methods for brain preservation, finding that ASC with SDS permeabilization matches aldehyde perfusion in preserving tissue structure.

This study shows that FICD-mediated AMPylation contributes to Parkinson's disease by promoting α-synuclein aggregation and protein dyshomeostasis in dopaminergic neurons.

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

This study uses blood vessel organoids to model systemic sclerosis vasculopathy and fibrosis, showing that SSc serum induces epigenetic and molecular changes linked to endothelial dysfunction and potential therapeutic targets.

This study shows that the adult murine hippocampus can recover near-physiological function after vitrification, preserving key features like synaptic plasticity and neuronal excitability.

The paper identifies the Feret diameter as a reliable quality marker for brain organoids and shows mesenchymal cells negatively impact organoid formation.

This study uses simulations to investigate if reduced reactivity in Parkinson's disease explains postural instability and increased muscle tone, finding that reduced reactivity increases muscle activation but not sway parameters.

This paper introduces a neuromusculoskeletal model for simulating upright standing postural control using sensor feedback, showing it can replicate physiological joint movements and reactive balance behavior.

The paper shows that reactivation of inactive X-chromosome alleles in female neural cells during differentiation enhances resilience to X-linked neurodevelopmental disorders.

This study examines electrophysiological and gene expression changes in dopaminergic neurons from Parkinson's disease patients and those with GBA1 mutations, identifying synaptic dysfunction and ECM pathway dysregulation.

The paper compares midbrain neurons from PD patients with mutations and sporadic PD, finding reduced synaptic activity and dysregulated extracellular matrix pathways as common features.

This study shows that acute exercise after skill practice improves long-term motor memory consolidation in Parkinson's disease patients, with effects only visible at 7-day retention.

The paper analyzes genetic integrity in iPSCs from the ForIPS consortium, identifying somatic variants and highlighting the need for individual clone evaluation.