Friederike Zunke

This study shows that FICD-mediated AMPylation contributes to Parkinson's disease by promoting α-synuclein aggregation and protein dyshomeostasis in dopaminergic neurons.

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

The paper develops a tagless LysoIP method to isolate lysosomes from clinical samples and human cell lines, revealing glycerophosphodiesters as potential biomarkers for lysosomal storage disorders.

The paper identifies key residues in SARS-CoV-2 variants that affect ACE2 binding using molecular dynamics simulations and energy decomposition.