Proximity determines donor candidacy during DNA double-stranded break homology directed repair
Charles D. Yeh, Lilly van de Venn, Susanne Kreutzer, Xinhe Zheng, Naomi C. Cantos, Luca V. Bechter, Dominic Mailänder, Markus Schröder, Robin Hofmann, Felix Ezequiel Gerbaldo, Alexandra Clemens, Beeke Wienert, Chris D. Richardson, Zacharias Kontarakis, Jacob E. Corn
The paper develops RaPID-seq to study homology search during HDR and finds that DSB proximity determines template candidacy, with distant sequences not efficiently searched despite sequence identity.
Cell Reports · Aug 1, 2026Peer-reviewedMolecular Biology