Zacharias Kontarakis

The paper identifies differences in liver and lung metastatic niches in breast cancer, showing liver promotes metastasis while lungs inhibit it, and highlights BMP2-producing endothelial cells in the liver as key players.

The paper develops RaPID-seq to study homology search during HDR and finds that DSB proximity determines template candidacy, with distant sequences not efficiently searched despite sequence identity.

CleanFinder is a scalable framework for analyzing genome editing outcomes, enabling detailed genotyping and comparison across diverse edit types and contexts.

This study shows WEE1 inhibitors work better with mRNA translation defects by activating GCN2, and suggests ways to reduce off-target effects.

This study identifies a stress response pathway linking nucleolar disruption to cellular quiescence and secretion, revealing its role in cancer progression.

In vivo prime editing corrects phenylketonuria in mice by repairing the Pah gene mutation and reducing blood phenylalanine levels.

The paper introduces MAGECS, a fast and cost-effective method to select genome-edited cells using magnetic sorting of surface antigens in Cas9-positive cells.

The paper shows that mutant mRNA degradation triggers transcriptional adaptation in zebrafish and mouse, leading to upregulation of related genes.