Author

Charles D. Yeh

ETH ZurichORCID 0000-0002-2707-6035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Jacob E. CorniD· 3 shared Beeke WienertiD· 2 shared Chris D. RichardsoniD· 2 shared Lilly van de VenniD· 2 shared Luca V. Bechter· 2 shared Markus SchröderiD· 2 shared Alexandra Clemens· 1 shared Ana GvozdenoviciD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Jacob E. CornORCID

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3 papers

Recent·Most cited

Proximity determines donor candidacy during DNA double-stranded break homology directed repair

Charles D. Yeh, Lilly van de Venn, Susanne Kreutzer, Xinhe Zheng, Naomi C. Cantos, Luca V. Bechter, Dominic Mailänder, Markus Schröder, Robin Hofmann, Felix Ezequiel Gerbaldo, Alexandra Clemens, Beeke Wienert, Chris D. Richardson, Zacharias Kontarakis, Jacob E. Corn

The paper develops RaPID-seq to study homology search during HDR and finds that DSB proximity determines template candidacy, with distant sequences not efficiently searched despite sequence identity.

Cell Reports · Aug 1, 2026Peer-reviewedMolecular Biology

Directed evolution of compact RNA-guided nucleases for enhanced activity in mammalian cells

F. V. Gorbenko, Irene Sala, Young-Yoon Lee, Lilly van de Venn, Charles D. Yeh, András Tálas, Tautvydas Karvelis, Gytis Druteika, Luca V. Bechter, Iryna Vykhlyantseva, Markus Schröder, Ana Gvozdenovic, Gerald Schwank, Virginijus Šikšnys, Jacob E. Corn

The paper improves the activity of compact RNA-guided nucleases in mammalian cells through directed evolution, resulting in variants with higher editing efficiency and reduced off-target effects.

Genome biology · Jun 16, 2026Peer-reviewedBioengineering

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

Beeke Wienert, Stacia K. Wyman, Chris D. Richardson, Charles D. Yeh, Pınar Akçakaya, Michelle J. Porritt, Michaela Morlock, Jonathan T. Vu, Katelynn R. Kazane, Hannah L. Watry, Luke M. Judge, Bruce R. Conklin, Marcello Maresca, Jacob E. Corn

This paper introduces DISCOVER-Seq, a method to detect CRISPR off-targets in vivo with single-base resolution, applicable to multiple Cas nucleases.

Science · Apr 19, 2019Peer-reviewedMolecular Biology