Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1 dependent manner and reveal proviral roles of UPF1.
Léa Prochasson, Makram Mghezzi-Habellah, Armelle Roisin, Martine Palma, Jean-Philippe Robin, Stève de Bossoreille, David Cluet, Malèke Mouelhi, Didier Décimo, Alexandra Desrames, Thibault Chaze, Mariette Matondo, Hélène Dutartre, Maria‐Isabel Thoulouze, Fabrice Lejeune, , Vincent Mocquet
This paper shows that HTLV-1 Rex hijacks CRM1 to retain UPF1 in the nucleus, inhibiting NMD and enabling UPF1 to support viral replication.
Nucleic Acids Research · May 10, 2025Peer-reviewedMolecular Biology