The paper develops an improved method to capture ribosome-associated proteins and shows viral infections remodel these proteins in a virus-specific manner, with functional implications for viral propagation.

bioRxiv · Jan 29, 2026 · PreprintMolecular Biology

Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1 dependent manner and reveal proviral roles of UPF1.

Léa Prochasson, Makram Mghezzi-Habellah, Armelle Roisin, Martine Palma, Jean-Philippe Robin, Stève de Bossoreille, David Cluet, Malèke Mouelhi, Didier Décimo, Alexandra Desrames, Thibault Chaze, Mariette Matondo, Hélène Dutartre, Maria‐Isabel Thoulouze, Fabrice Lejeune, , Vincent Mocquet

This paper shows that HTLV-1 Rex hijacks CRM1 to retain UPF1 in the nucleus, inhibiting NMD and enabling UPF1 to support viral replication.

Nucleic Acids Research · May 10, 2025Peer-reviewedMolecular Biology

Rapid delivery of RNase H1 enables replication fork progression under stress independently of R-loop resolution

Amandine Basille, Yi‐Ching Lin, Connor Kirke, David Cluet, Yara Bawadi, Laetitia Vachez, Virgile Dervieux, Laura Guiguettaz, Pascal Bernard, Stephan Hamperl, Philippe Pasero, Emiliano P. Ricci, Vincent Vanoosthuyse

This study shows that rapid delivery of RNase H1 rescues replication fork progression under stress without affecting R-loops.

bioRxiv · Feb 27, 2025 · PreprintMolecular Biology

Translation-dependent and independent mRNA decay occur through mutually exclusive pathways that are defined by ribosome density during T Cell activation.

Blandine C. Mercier, Emmanuel Labaronne, David Cluet, Laura Guiguettaz, Nicolas Fontrodona, Alicia A. Bicknell, Antoine Corbin, Mélanie Wencker, Fabien Aubé, Laurent Modolo, Karina Jouravleva, Didier Auboeuf, Melissa J. Moore, Emiliano P. Ricci

The paper shows that mRNA decay during T cell activation occurs through translation-dependent and independent pathways, with ribosome density determining the pathway used.

Genome Research · Mar 20, 2024Peer-reviewedGenomics

Gradient in cytoplasmic pressure in the germline cells controls overlying epithelial cell morphogenesis

Laurie-Anne Lamiré, Pascale Milani, Gaël Runel, Annamária Kiss, Leticia Arias, Blandine Vergier, Stève de Bossoreille, Pradeep Kumar Das, David Cluet, Arezki Boudaoud, Muriel Grammont

The paper shows that a gradient of cytoplasmic pressure in nurse cells controls epithelial cell flattening via TGFβ signaling in Drosophila ovaries.

PLoS Biology · Nov 30, 2020Peer-reviewedDevelopmental Biology

Split-ends is modulating lipid droplet content in adult Drosophila glial cells and is protective against paraquat toxicity.

Victor Girard, Valérie Goubard, Matthieu Querenet, Laurent Seugnet, Laurent Pays, Serge Nataf, Eloïse Dufourd, David Cluet, Bertrand Mollereau, Nathalie Davoust

The paper investigates the role of Spen in glial lipid metabolism and its protective effect against paraquat toxicity in Drosophila.

Scientific Reports · Nov 18, 2020Peer-reviewedNeuroscience

Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3 HDAC complex

Flore Beurton, Przemysław Stempor, Matthieu J. Caron, Alex Appert, Dong Yan, Ron A.-J. Chen, David Cluet, Yohann Couté, Marion Herbette, Ni Huang, Hélène Polvèche, Martin Spichty, Cécile Bedet, Julie Ahringer, Francesca Palladino

The paper identifies a physical and functional interaction between CFP-1 and the Sin3 HDAC complex in C. elegans, showing their coordinated regulation of gene expression.

Nucleic Acids Research · Oct 3, 2019Peer-reviewedGenomics