Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia
Deena B. Snoke, Jos L. J. van der Velden, Emma R. Bellafleur, Jacob S. Dearborn, Sean M. Lenahan, Alexandra E. Beal, Reem Aboushousha, Skyler C. J. Heininger, Jennifer L. Ather, Madeleine M. Mank, Hailey M. Sarausky, Daniel Stephenson, Julie A. Reisz, Angelo D’Alessandro, Devdoot S. Majumdar, , Michael J. Toth
This study develops a novel mouse model of human lung cancer cachexia that exhibits early adipose tissue wasting and metabolic reprogramming, mirroring human disease features.
Cell Reports · Sep 1, 2025Peer-reviewedCancer Biology