Author

Madeleine M. Mank

University of VermontORCID 0000-0002-0617-4736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Matthew E. PoynteriD· 4 shared V. Amanda FastiggiiD· 3 shared Jennifer L. AtheriD· 2 shared Alexandra E. Beal· 1 shared Angelo D’AlessandroiD· 1 shared Bennett A. LandmaniD· 1 shared Daniel StephensoniD· 1 shared David Joseph SewardiD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCell Biology

Matthew E. PoynterORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia

Deena B. Snoke, Jos L. J. van der Velden, Emma R. Bellafleur, Jacob S. Dearborn, Sean M. Lenahan, Alexandra E. Beal, Reem Aboushousha, Skyler C. J. Heininger, Jennifer L. Ather, Madeleine M. Mank, Hailey M. Sarausky, Daniel Stephenson, Julie A. Reisz, Angelo D’Alessandro, Devdoot S. Majumdar, , Michael J. Toth

This study develops a novel mouse model of human lung cancer cachexia that exhibits early adipose tissue wasting and metabolic reprogramming, mirroring human disease features.

Cell Reports · Sep 1, 2025Peer-reviewedCancer Biology

Acidosis Licenses the NLRP3 Inflammasome-Inhibiting Effects of Beta-Hydroxybutyrate and Short-Chain Carboxylic Acids

Madeleine M. Mank, Kaitlyn A Zoller, V. Amanda Fastiggi, Jennifer L. Ather, Matthew E. Poynter

This study shows that BHB and SCCAs inhibit NLRP3 inflammasome activation under acidic conditions, mediated by GPR41/FFAR3, suggesting their potential as anti-inflammatory agents during metabolic stress.

bioRxiv · May 1, 2025 · PreprintImmunology

Beta-Hydroxybutyrate Inhibits Bronchial Smooth Muscle Contraction

V. Amanda Fastiggi, Madeleine M. Mank, Matthew A. Caporizzo, Matthew E. Poynter

This study shows beta-hydroxybutyrate inhibits bronchial smooth muscle contraction in vitro and ex vivo, suggesting it could be a therapeutic agent for asthma.

bioRxiv · Feb 24, 2025 · PreprintCell Biology

Beta-Hydroxybutyrate Attenuates Bronchial Smooth Muscle Pro-Inflammatory Cytokine Production

V. Amanda Fastiggi, Madeleine M. Mank, Matthew E. Poynter

This study shows that beta-hydroxybutyrate reduces pro-inflammatory cytokine production in bronchial smooth muscle cells by activating FFAR3.

bioRxiv · Feb 19, 2025 · PreprintCell Biology