Author

Alexandra J. Savage

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Cassidy N. HemphilliD· 3 shared Eric A. Rhon‐CalderóniD· 3 shared Marisa S. BartolomeiiD· 3 shared Richard M. SchultziD· 3 shared Ana Domingo-MuelasiD· 2 shared Christopher J. KrappiD· 2 shared Laren RiescheiD· 2 shared Nicolas PlachtaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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3 shared papersDevelopmental Biology

Cassidy N. HemphillORCID

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3 papers

Recent·Most cited

Ultra-low oxygen tension during in vitro fertilization improves embryonic and adult outcomes in mice

Cassidy N. Hemphill, Eric A. Rhon‐Calderón, Alexandra J. Savage, Ana Domingo-Muelas, Christopher J. Krapp, Nicolas Plachta, Richard M. Schultz, Marisa S. Bartolomei

This study shows culturing mouse embryos at 2% oxygen improves embryonic and adult outcomes compared to 5% oxygen, by enhancing cell number, chromatin structure, and metabolic function.

bioRxiv · Jul 13, 2026 · PreprintDevelopmental Biology

In Vitro Fertilization Accelerates Female Reproductive Aging Through Early Ovarian Failure

Eric A. Rhon‐Calderón, Cassidy N. Hemphill, Alexandra J. Savage, Ana Domingo-Muelas, Zhengfeng Liu, Christopher J. Krapp, Laren Riesche, Nicolas Plachta, Richard M. Schultz, Marisa S. Bartolomei

This study shows that in vitro fertilization (IVF) accelerates reproductive aging in female mice by causing premature ovarian failure, with altered ovarian function and epigenetic changes.

bioRxiv · Oct 13, 2025 · PreprintDevelopmental Biology

In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects

Eric A. Rhon‐Calderón, Cassidy N. Hemphill, Alexandra J. Savage, Laren Riesche, Richard M. Schultz, Marisa S. Bartolomei

This study shows that IVF in mice leads to reproductive and molecular changes in male offspring, which are transmitted across generations.

JCI Insight · Mar 4, 2025Peer-reviewedDevelopmental Biology