Christopher J. Krapp

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

This study shows culturing mouse embryos at 2% oxygen improves embryonic and adult outcomes compared to 5% oxygen, by enhancing cell number, chromatin structure, and metabolic function.

The paper develops and validates Sparse-Seq, a low-coverage sequencing method for accurate quantification of 5mC and 5hmC levels, showing it is more accessible and less variable than mass spectrometry.

This study shows that in vitro fertilization (IVF) accelerates reproductive aging in female mice by causing premature ovarian failure, with altered ovarian function and epigenetic changes.