Marisa S. Bartolomei

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

This study shows culturing mouse embryos at 2% oxygen improves embryonic and adult outcomes compared to 5% oxygen, by enhancing cell number, chromatin structure, and metabolic function.

The paper develops and validates Sparse-Seq, a low-coverage sequencing method for accurate quantification of 5mC and 5hmC levels, showing it is more accessible and less variable than mass spectrometry.

This study shows TET1's non-catalytic activity helps maintain chromatin structure to prevent abnormal methylation in male germ cells.

This study shows that in vitro fertilization (IVF) accelerates reproductive aging in female mice by causing premature ovarian failure, with altered ovarian function and epigenetic changes.

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

ToxiTaRGET provides a multi-omics resource of molecular responses to toxicants in mice, enabling researchers to explore transcriptomic and epigenomic changes across tissues and life stages.

This study examines how early-life exposure to environmental toxicants alters TE chromatin accessibility and expression in mouse liver, revealing exposure-specific and sex-dependent effects.

The paper shows early-life toxicant exposure reprograms epigenomic aging, altering gene expression in liver cells and disease risk in adulthood.

This study shows that IVF in mice leads to reproductive and molecular changes in male offspring, which are transmitted across generations.

The paper develops low-input and single-cell methods for Infinium DNA methylation BeadChips, improving detection rates and data quality for small sample sizes.

This study shows that TET1's catalytic activity is essential for reprogramming imprinting control regions and sperm-specific hypomethylated regions during germline development.

This study investigates the role of H19/Igf2 dysregulation in cardiac and placental defects in SRS-like mouse models, showing disrupted ECM and endothelial proliferation pathways.

This paper develops a high-throughput DNA methylation array and atlas for mice, revealing tissue-specific methylation patterns and their associations with aging, differentiation, and disease.

This study examines sex-specific metabolic and transcriptomic effects of IVF in mice, finding sex-dimorphic dysregulation of SREBP pathways and placental DNA methylation changes linked to cholesterol levels.

The paper uses allele-specific RNA imaging to show that allelic imbalances in tissues can result from transcriptional bursting and low mRNA abundance.