PIEZO1 mediates mechanosensing and myofibroblastic activation of synovial fibroblasts in post-traumatic osteoarthritis
Easton C. Farrell, Aanya Mohan, Alexandra M Kahn, Eleanor Knight, Hunter Stabile, Morgan Whitaker, Sung Yeon Kim, Lindsey Lammlin, Michael D. Newton, George Esteve, Ranveer R Singh, Scarlet C. Howser, Selina Z Lin, Huong X Tran, Danny M. T. Nguyen, , Tristan Maerz
This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.
bioRxiv · Oct 15, 2026 · PreprintCell Biology