Carla R. Scanzello

PIEZO1 mediates mechanosensing and myofibroblastic activation of synovial fibroblasts in post-traumatic osteoarthritis

This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.

Mechano-activated synovial cells instigate OA-like disease progression in the absence of joint injury

This study shows that altering synovial cell mechanotransduction drives OA-like disease without joint injury, with partial effects on symptoms versus structural damage.

NERVE GROWTH FACTOR IS SUFFICIENT TO CAUSE MULTIPLE OSTEOARTHRITIS-RELEVANT PATHOLOGICAL FEATURES IN NAIVE MURINE KNEE JOINTS

This study shows that repeated NGF injections into mouse knees cause multiple OA-like features without cartilage damage.

CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis

The study shows CD14 is critical for pain and inflammation in post-traumatic osteoarthritis and that blocking CD14 can reduce pain and mobility loss.

Mechano-activation of synovial fibroblasts and macrophages during OA progression in the dynamically stiffening synovial microenvironment

This study investigates how synovial microenvironment stiffness changes during OA progression and how it affects fibroblast and macrophage behavior through mechanosignaling and cell-cell interactions.

CD14-deficiency protects against osteoarthritic subchondral bone sclerosis via enhanced osteoclastogenesis following joint injury

This study shows CD14-deficiency protects against osteoarthritis-related subchondral bone sclerosis by enhancing osteoclastogenesis post-injury in mice.

Synovial fibroblasts support vascular function in an acute injury-on-a-chip model

This study develops an injury-on-a-chip model to investigate synovial fibroblasts' role in vascular function during acute inflammation, finding they support vascular health rather than drive disease.