Samuel H. Light

SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol

The paper identifies SpiE as a gut microbial enzyme that, along with SpiR, converts cholesterol to coprostanol, and shows its correlation with stool coprostanol levels and antibiotic impact.

Microbiome histidine competition mediates dietary control of systemic imidazole propionate

This study shows dietary glutamate influences ImP production via microbial competition, affecting glucose tolerance and systemic ImP levels.

Gut Bacteria Metabolize Natural and Synthetic Steroid Hormones via the Reductive OsrABC Pathway

The paper identifies a novel gut bacterial pathway for steroid hormone metabolism and shows its impact on drug efficacy in Crohn's disease.

DNA-utilization loci enable exogenous DNA metabolism in gut Bacteroidales

This study identifies DNA-utilization loci in gut Bacteroidales that metabolize exogenous DNA into deaminated nucleobases, revealing a conserved pathway with implications for host-microbe interactions.

Quantitative insights into the efficacy of genome-resolved surveys of microbial communities through ribosomal protein phylogeography and EcoPhylo

The paper introduces EcoPhylo, a computational workflow to assess genome recovery rates in microbial communities using ribosomal protein phylogeography, applied to human gut and oral cavity data.

Versatile roles of protein flavinylation in bacterial extracyotosolic electron transfer

This study investigates the role of protein flavinylation in bacterial extracytosolic electron transfer by analyzing genomic, structural, and biochemical data.