Epidermal Growth Factor signaling acts directly and through a sedation neuron to depolarizes a sleep-active neuron following cellular stress
Jan Konietzka, Maximilian Fritz, Silvan Spiri, Rebecca D. McWhirter, Andreas Leha, Sierra D. Palumbos, Wagner Steuer Costa, Alexandra Oranth, ALEXANDER R. GOTTSCHALK, David M. Miller, Alex Hajnal, Henrik Bringmann
The paper identifies EGFR signaling in the RIS neuron and its indirect activation via the ALA neuron as mechanisms for sleep induction following cellular stress in C. elegans.
Current Biology · Dec 12, 2019Peer-reviewedNeuroscience